Discoidin Domain Receptors in Health and Disease by Rafael Fridman & Paul H. Huang

Author:Rafael Fridman & Paul H. Huang
Language: eng
Format: epub
Publisher: Springer New York, New York, NY

9.9 Perspectives

DDR1 overexpression is found in a wide variety of different human cancers as mentioned above suggesting that it has a function in tumor progression. As shown in Fig. 9.3, DDR1 may have a critical role in adhesion, migration, and invasion of EOC metastasis, but additional study is needed. As a diagnostic tool, elevated DDR1 protein expression levels may be predictive for EOC [67]. However, using DDR1 levels as a marker for EOC is not necessarily specific and may indicate various other malignancies. DDR1 expression levels in body fluid or serum may have clinical prognostic value as a biomarker for cancer in a more general sense. The shedding of the DDR1 ectodomain by membrane-type MMP may add another level to regulate as well as to detect these receptors [129]. These biomarkers could be found in serum of EOC patients. Such understanding is critical for developing selective DDR inhibitors or treatments that can alter activity indirectly to result in novel and safe therapies for the treatment of a broad range of diseases including cancer.

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